What Is CJC-1295 (No DAC)? A Complete Research Overview
This content is for laboratory research purposes only. Not for human or animal use.
CJC-1295 (No DAC) is a synthetic peptide of 29 amino acids, an analogue of Growth Hormone-Releasing Hormone (GHRH). Studied in the laboratory for its role in growth hormone receptor binding and intracellular signalling, it is supplied as a lyophilised powder. This guide explains what the peptide is, how it works, what it is used for in research, and the purity and storage points that matter when working with it.
Table of Contents
What Is CJC-1295 (No DAC)?
CJC-1295 (No DAC) is a synthetic peptide consisting of 29 amino acids. It is an analogue of Growth Hormone-Releasing Hormone (GHRH) and is supplied as a lyophilised powder for controlled laboratory research investigations.
In scientific literature, CJC-1295 (No DAC) has been examined in experimental studies investigating peptide-receptor interaction dynamics, growth hormone signalling, and intracellular pathways within defined laboratory models.
How It Works
CJC-1295 (No DAC) acts as a GHRH analogue, binding to the GHRH receptor on pituitary cells. This interaction stimulates the release of growth hormone, which triggers downstream signalling cascades.
Unlike CJC-1295 with DAC, this version does not contain a Drug Affinity Complex (DAC), resulting in a shorter half-life and different pharmacokinetic profile. Research suggests it may be useful for studies investigating pulsatile growth hormone release patterns.
CJC-1295 (No DAC) Research Applications
CJC-1295 (No DAC) has been referenced in controlled in-vitro and experimental laboratory studies examining:
- Growth hormone receptor binding dynamics: Research into receptor-ligand interactions
- Intracellular signalling pathways: Studies on downstream cellular responses
- Pituitary cell response mechanisms: Investigations into hormone secretion patterns
- Neuroendocrine research: Studies on the interaction between the nervous and endocrine systems
- Peptide-receptor interaction behaviour: Research into binding affinity and specificity
CJC-1295 (No DAC) Purity and Quality
For reproducible results, confirm the identity and purity of the material before use. The specifications below are a useful checklist.
| Property | Specification |
|---|---|
| Appearance | White lyophilised powder |
| HPLC purity | ≥98% (HPLC-verified) |
| Sequence | 29 amino acids |
| Molecular weight | ~3367.9 g/mol |
| Storage | -20°C, protected from light and moisture |
| COA | Confirms purity, molecular weight and peptide sequence |
Truncated sequences and impurities can confound an assay, so a batch Certificate of Analysis confirming the sequence and HPLC purity is essential. See why peptide purity matters for more on why this underpins reliable research data.
Reconstitution and Handling
The peptide is supplied as a lyophilised powder and is brought into solution before use. For aqueous preparations, bacteriostatic water is commonly used, as its preservative allows a single vial to serve multiple withdrawals under sterile technique. Bring the vial and solvent to room temperature, add the solvent gently down the inside wall, and swirl until fully dissolved. Aliquot the reconstituted solution and store frozen (-80°C for longer-term storage) to minimise freeze-thaw cycles.
Related Research Compounds
- Ipamorelin — growth hormone research.
- Tesamorelin — growth hormone research.
- IGF-1 LR3 — growth factor research.
- GHRP-6 — growth hormone research.
Frequently Asked Questions
What is CJC-1295 (No DAC) used for in research?
CJC-1295 (No DAC) is studied for its potential role in growth hormone receptor binding, intracellular signalling, and neuroendocrine research.
How is CJC-1295 (No DAC) supplied?
CJC-1295 (No DAC) is supplied as a lyophilised powder in sterile vials, ready for reconstitution in research settings.
What purity should I look for?
For most research applications, ≥98% HPLC purity is recommended. Higher purity (≥99%) is preferred for sensitive assays.
How should CJC-1295 (No DAC) be stored?
CJC-1295 (No DAC) should be stored at -20°C, protected from light and moisture. Once reconstituted, aliquot and store at -80°C.
What is the molecular weight of CJC-1295 (No DAC)?
The molecular weight of CJC-1295 (No DAC) is approximately 3367.9 g/mol.
What is the difference between CJC-1295 with DAC and without DAC?
CJC-1295 without DAC does not contain the Drug Affinity Complex, resulting in a shorter half-life compared to the DAC version. This makes it suitable for studies investigating pulsatile growth hormone release.
For Research at Optimus Labs
Optimus Labs supplies CJC-1295 (No DAC) as a high-purity lyophilised powder, HPLC-verified and batch-tested, with a Certificate of Analysis confirming purity, molecular weight and peptide sequence. Orders ship from the UK with tracked delivery. Explore the rest of the research catalogue for related laboratory compounds, or our overview of the most popular research peptides in the UK.
References
- Alba M, et al. (2006). Once-daily administration of CJC-1295, a long-acting GHRH analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. — pubmed.ncbi.nlm.nih.gov
- Moulin C, et al. (2005). CJC-1295 induces GH secretion in a long-acting manner in rats. Endocrine. — pubmed.ncbi.nlm.nih.gov
- Jette L, et al. (2009). Pharmacokinetics and pharmacodynamics of CJC-1295 in healthy subjects. J Clin Pharmacol. — pubmed.ncbi.nlm.nih.gov
